How it works
Nerves, brain, blood vessels and fascia
Trials ask whether acupuncture works. Another line of research asks how. With brain scans and anatomy, it shows that a needle is not a placebo pill: it is a real signal to the nervous system.
Brain imaging
Brain scans (fMRI and PET) show that needling changes activity in areas that process pain, emotion and stress. In one study at the University of Michigan, women with fibromyalgia had eight sessions of acupuncture. PET scans showed that acupuncture increased the brain’s capacity to use its own pain-relieving opioid system, in regions that process and dampen pain, and the larger this change, the less pain they felt. Sham needling eased pain too, but through a different mechanism in the brain (Harris and colleagues, NeuroImage, 2009).
This is the part of the research I find most convincing as a scientist: we can now see, on a scan, the nervous system respond to the needle.
The anatomy of acupuncture points
Dr Poney Chiang, PhD in biomedical research at the University of Toronto and an acupuncturist, maps acupuncture points onto the nerves that lie beneath them. Many classical points sit where nerves come close to the surface, and his current research uses MRI to relate scalp points to the brain regions under them. His work explains, in the language of neuroscience, why the old points work.
Medical acupuncture anatomy
Dr Narda G. Robinson, DO, DVM, a leading teacher of medical acupuncture, describes acupuncture as neuromodulation: the needle acts on motor, sensory and autonomic nerves, and the result depends on which nerves are reached and how they are stimulated. Dry needling, electro-acupuncture and acupressure are all ways of giving that signal.
She shows how many classical points sit exactly where the nervous system is most responsive. Trigger points, for example, form mostly in the middle of a muscle belly and where muscle meets tendon, where specialised nerve endings cluster. Points on the back share their spinal nerve supply with the organs beneath, so tension found by palpation along the spine can point to what is happening deeper inside. This is why, in my sessions, careful palpation guides where I place each needle (Robinson, Interactive Medical Acupuncture Anatomy).
Segmental anatomy
Dr Ingrid Wancura-Kampik’s Segmental Anatomy: The Key to Mastering Acupuncture, Neural Therapy and Manual Therapy maps how each spinal nerve supplies its own segment of skin, muscle, bone and inner organs. Acupuncture points line up with this map. A needle in the skin or muscle of one segment reaches the same spinal level as the organs it shares nerves with. That gives a clear anatomical reason why a point on the back or the abdomen can influence digestion, breathing or pain deeper in the body.
Motor points and sports medicine
Matt Callison, author of Sports Medicine Acupuncture (2019) and one of my teachers, has spent over 20 years dissecting cadavers to map exactly where motor nerves enter each muscle. These motor points match many classical acupuncture points, and needling them, often with electro-acupuncture, is central to how he treats sports injuries and rehabilitation. It is one of the clearest bridges between Chinese medicine and Western anatomy.
Blood vessels, nerves and the classical texts
Dr Donald Kendall, an engineer turned doctor of Oriental medicine who did acupuncture research at UCLA, went back to the original Chinese texts in The Dao of Chinese Medicine (Oxford University Press, 2002). He argues that the classics describe a physical body: mai are blood vessels, qi is closer to the vital air and nourishment they carry than to a mysterious “energy”, and acupuncture points sit at nodes where nerves and blood vessels meet. In his reading, the ancient doctors were careful anatomists, and their medicine fits with modern physiology.
Scalp acupuncture
Professor Tianjun Wang, PhD, guest professor at Nanjing University of Chinese Medicine and one of my teachers, works with scalp acupuncture for the brain: stroke, Parkinson’s, headaches, anxiety and depression. His book, Acupuncture for Brain (Springer, 2021), brings together the classical theory and modern research on how needling the scalp influences the brain.
Fascia and connective tissue
Simply: fascia is the thin web of connective tissue that wraps every muscle and organ. When I gently turn a needle, this tissue grips it and winds around it, a little like spaghetti on a fork. The tissue is stretched, and the cells inside it respond. This is one reason why acupuncture can release tightness and ease pain in the area being treated.
In more detail: Dr Helene Langevin and her team at the University of Vermont showed that rotating a needle increases the force needed to pull it out, because connective tissue winds around it, not because the muscle contracts (FASEB Journal, 2002). In a second study, about 80% of acupuncture points in the arm lay on planes of connective tissue between or within muscles (Anatomical Record, 2002). Once the tissue is wound around the needle, small movements stretch the surrounding network, and the fibroblasts, the cells that build and maintain fascia, change shape and send chemical signals. A 2025 review describes fibroblasts as key cellular targets of acupuncture.
To be honest about the limits: this is strong evidence for local effects, such as tissue tone, mobility, circulation and pain signals. It does not prove that fascia explains everything acupuncture does, or that meridians are simply fascial planes. Fascia works alongside the nervous system, not instead of it.